Diagnostic accuracy of a three-protein signature in women with suspicious breast lesions: a multicenter prospective trial.

ABSTRACT:

Background

Mammography screening has been proven to detect breast cancer at an early stage and reduce mortality; however, it has low accuracy in young women or women with dense breasts. Blood-based diagnostic tools may overcome the limitations of mammography. This study assessed the diagnostic performance of a three-protein signature in patients with suspicious breast lesions.

Findings

This trial (MAST; KCT0004847) was a prospective multicenter observational trial. Three-protein signature values were obtained using serum and plasma from women with suspicious lesions for breast malignancy before tumor biopsy. Additionally, blood samples from women who underwent clear or benign mammography were collected for the assays. Among 642 participants, the sensitivity, specificity, and

SUBMITTER: Lee ES 

PROVIDER: S-EPMC9930228 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature