Is prior cancer history a hindrance for non-small cell lung cancer patients to participate in clinical trials?

ABSTRACT:

Background

This study aimed to explore the effect of a prior cancer history on the survivals of resected non-small cell lung cancer (NSCLC) patients.

Methods

Kaplan-Meier method with a log-rank test was used to compare overall survival (OS) and disease-free survival (DFS) between groups. Propensity score matching (PSM) method was used to reduce bias. The least absolute shrinkage and selection operator (LASSO)-penalized Cox multivariable analysis was used to identify the prognostic factors.

Results

A total of 4,102 eligible cases were included in this study. The rate of patients with a prior cancer was 8.2% (338/4,102). Patients with a prior cancer tended to be younger and have early-stage tumors when compared with those without prior cancer. Before PSM, the survivals

SUBMITTER: Cai JS 

PROVIDER: S-EPMC9930244 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature