Whole-genome sequence of Macaca fascicularis: liver tissue.

ABSTRACT:

Objectives

Thrombocytopenia is a condition that causes a low amount of blood platelets. Platelets are blood cells that play an essential role in blood coagulation. Therefore, thrombocytopenia can put the patient at risk for mild to severe bleeding. Thrombocytopenia is caused by a decrease in platelet production in the bone marrow or by a drug or immune system problem when production is normal. In particular, in some ASO-induced thrombocytopenia, the mechanism is not clear. Therefore, whole genome sequencing (WGS) was performed to discover genetic differences that affect thrombocytopenia and individual susceptibility to drugs between normal and reduced platelet monkeys despite administering the same ASO.

Data description

Three antisense oligonucleotide (ASO) substances were i

SUBMITTER: Seo EH 

PROVIDER: S-EPMC9930273 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature