Decreased incidence of Hirschsprung-associated enterocolitis during COVID-19 across United States Children's hospitals

ABSTRACT:

Background

The Coronavirus Disease 2019 pandemic provided a natural experiment to study the effect of social distancing on the risk of developing Hirschsprung's Associated Enterocolitis (HAEC).

Methods

Using the Pediatric Health Information System (PHIS), a retrospective cohort study of children (<18 years) with Hirschsprung's Disease (HSCR) across 47 United States children's hospitals was performed. The primary outcome was HAEC admissions per 10,000 patient-days. The exposure (COVID-19) was defined as April 2020–December 2021. The unexposed (historical control) period was April 2018–December 2019. Secondary outcomes included sepsis, bowel perforation, intensive care unit (ICU) admission, mortality, and length of stay.

Results

Overall, we included 5707 patients w

SUBMITTER:  

PROVIDER: S-EPMC9930381 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature