Cervical spinal cord atrophy in amyotrophic lateral sclerosis across disease stages.

ABSTRACT:

Objective

Spinal cord degeneration is a hallmark of amyotrophic lateral sclerosis. The assessment of gray matter and white matter cervical spinal cord atrophy across clinical stages defined using the King's staging system could advance the understanding of amyotrophic lateral sclerosis progression.

Methods

We assessed the in vivo spatial pattern of gray and white matter atrophy along cervical spinal cord (C2 to C6 segments) using 2D phase-sensitive inversion recovery imaging in a cohort of 44 amyotrophic lateral sclerosis patients, evaluating its change across the King's stages and the correlation with disability scored by the amyotrophic lateral sclerosis functional rating scale revised (ALSFRS-R) and disease duration. A mathematical model inferring the potential onset of c

SUBMITTER: Nigri A 

PROVIDER: S-EPMC9930423 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature