Adipose-derived mesenchymal stem cells overexpressing prion improve outcomes via the NLRP3 inflammasome/DAMP signalling after spinal cord injury in rat.

ABSTRACT: Traumatic spinal cord injury (SCI) is a highly destructive disease in human neurological functions. Adipose-derived mesenchymal stem cells (ADMSCs) have tissue regenerations and anti-inflammations, especially with prion protein overexpression (PrPc^OE ). Therefore, this study tested whether PrPc^OE -ADMSCs therapy offered benefits in improving outcomes via regulating nod-like-receptor-protein-3 (NLRP3) inflammasome/DAMP signalling after acute SCI in rats. Compared with ADMSCs only, the capabilities of PrPc^OE -ADMSCs were significantly enhanced in cellular viability, anti-oxidative stress and migration against H₂ O₂ and lipopolysaccharide damages. Similarly, PrPc^OE -ADMSCs significantly inhibited the inflammatory patterns of Ra

SUBMITTER: Yin TC 

PROVIDER: S-EPMC9930430 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature