Cystathionine γ-lyase S-sulfhydrates SIRT1 to attenuate myocardial death in isoprenaline-induced heart failure.

ABSTRACT:

Objective

Hydrogen sulfide (H₂S), the third gasotransmitter, plays a critical role in protecting against heart failure. Sirtuin-1 (SIRT1) is a highly conserved histone deacetylase that has a protective role in the treatment of heart failure by regulating the deacetylation of some functional proteins. This study investigates the interaction between SIRT1 and H₂S in heart failure and the underlying mechanisms.

Methods and results

Using endogenous H₂S-generating enzyme cystathionine γ-lyase (CSE) knockout mice, we found that CSE deficiency aggravated isoprenaline-induced cardiac injury. Treatment with H₂S attenuated atrial natriuretic peptide level, brain natriuretic peptide level, improved cardiac function. Moreover, H₂S t

SUBMITTER: Wu D 

PROVIDER: S-EPMC9930813 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature