Considering strategies for SNP selection in genetic and polygenic risk scores.
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ABSTRACT:
SUBMITTER: St-Pierre J
PROVIDER: S-EPMC9930898 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Considering strategies for SNP selection in genetic and polygenic risk scores.
St-Pierre Julien J Zhang Xinyi X Lu Tianyuan T Jiang Lai L Loffree Xavier X Wang Linbo L Bhatnagar Sahir S Greenwood Celia M T CMT
Frontiers in genetics 20221025
Genetic risk scores (GRS) and polygenic risk scores (PRS) are weighted sums of, respectively, several or many genetic variant indicator variables. Although they are being increasingly proposed for clinical use, the best ways to construct them are still actively debated. In this commentary, we present several case studies illustrating practical challenges associated with building or attempting to improve score performance when there is expected to be heterogeneity of disease risk between cohorts ...[more]
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