Neural correlates of subjective cognitive decline in adults at high risk for Alzheimer's disease.

ABSTRACT:

Introduction

Recently, interest has emerged in subjective cognitive decline (SCD) as a potential precursor to Alzheimer's disease (AD) dementia. Whether individuals with SCD harbor brain alterations in midlife, when AD-related pathology begins, is yet to be elucidated. Furthermore, the role of apolipoprotein ε4 (APOE ε4) allele, a robust AD risk factor, in the relationship between SCD and brain alterations is unknown. We examined whether APOE genotype modulates the association of SCD with brain measures in individuals at high AD risk.

Methods

Middle-aged adults with parental history of AD dementia underwent magnetic resonance imaging (MRI) and the Memory Functioning Questionnaire. Regression analysis tested the extent to which SCD was associated with act

SUBMITTER: Ben-Ami L 

PROVIDER: S-EPMC9930909 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature