Influence of Micro-RNA-423 Gene Variation on Risk and Characteristics of Breast Cancer.

ABSTRACT:

Background

Micro-RNAs (miRNAs) are post-transcriptional regulators of gene expression that are abundantly expressed in a variety of cancers, including breast cancer. The mechanism of miRNAs in breast cancer oncogenesis is poorly understood. The goal of this study was to determine if there was a link between the miR-423 rs6505162 gene variation and breast cancer susceptibility among Egyptian patients.

Methods

This was a case control study that included 120 female patients with pathologically confirmed breast cancer and 120 healthy controls. The patients and controls were genotyped for miR-423 rs6505162 polymorphism by real time PCR. The association of breast cancer patients' genotypic variant and clinicopathological characteristics was analyzed.

Results

Breast cancer p

SUBMITTER: El-Ashry AH 

PROVIDER: S-EPMC9930970 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature