Identification of oxytocin receptor activating chemical components from traditional Japanese medicines.

ABSTRACT: Oxytocin (Oxt) is known to regulate social communication, stress and body weight. The activation of Oxt receptors (OTR) has clinical potential to abate stress disorders and metabolic syndrome. Kamikihito (KKT) is a traditional Japanese medicine used to treat psychological stress-related disorders. We investigated the effects of KKT, its ingredients and chemical components on Oxt neurons and OTR. C-Fos expression was examined after oral and peripheral administration of KKT in rats. Electrophysiological change of Oxt neurons and Oxt release upon application of KKT were measured in rat brain slice. The direct effect of KKT, its ingredients and its chemical components were examined by cytosolic Ca²⁺([Ca²⁺]_i) measurement in Oxt neurons and OTR-expressing HEK293

SUBMITTER: Maejima Y 

PROVIDER: S-EPMC9931015 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature