Periodontal Inflamed Surface Area (PISA) associates with composites of salivary cytokines

ABSTRACT:

Background

Periodontal disease (PerioD) is a chronic, complex inflammatory condition resulting from the interaction between subgingival dysbiotic bacteria and the host immune response leading to local inflammation. Since periodontal inflammation is characterized by multiple cytokines effects we investigated whether Periodontal Inflamed Surface Area (PISA), a continuous measure of clinical periodontal inflammation is a predictor of composite indexes of salivary cytokines.

Methods and findings

In a cross-sectional study of 67 healthy, well-educated individuals, we evaluated PISA and several cytokines expressed in whole stimulated saliva. Two salivary cytokine indexes were constructed using weighted and unweighted approaches based on a Principal Component Analysis [named Cyt

SUBMITTER: Tang V 

PROVIDER: S-EPMC9931150 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature