Autolysosomal activation combined with lysosomal destabilization efficiently targets myeloid leukemia cells for cell death.

ABSTRACT:

Introduction

Current cancer research has led to a renewed interest in exploring lysosomal membrane permeabilization and lysosomal cell death as a targeted therapeutic approach for cancer treatment. Evidence suggests that differences in lysosomal biogenesis between cancer and normal cells might open a therapeutic window. Lysosomal membrane stability may be affected by the so-called 'busy lysosomal behaviour' characterized by higher lysosomal abundance and activity and more intensive fusion or interaction with other vacuole compartments.

Methods

We used a panel of multiple myeloid leukemia (ML) cell lines as well as leukemic patient samples and updated methodology to study auto-lysosomal compartment, lysosomal membrane permeabilization and lysosomal cell death.

Resul

SUBMITTER: Shah H 

PROVIDER: S-EPMC9931186 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature