Molecular characterization of the intact mouse muscle spindle using a multi-omics approach.

ABSTRACT: The proprioceptive system is essential for the control of coordinated movement, posture, and skeletal integrity. The sense of proprioception is produced in the brain using peripheral sensory input from receptors such as the muscle spindle, which detects changes in the length of skeletal muscles. Despite its importance, the molecular composition of the muscle spindle is largely unknown. In this study, we generated comprehensive transcriptomic and proteomic datasets of the entire muscle spindle isolated from the murine deep masseter muscle. We then associated differentially expressed genes with the various tissues composing the spindle using bioinformatic analysis. Immunostaining verified these predictions, thus establishing new markers for the different spindle tissues. Utilizing these mark

SUBMITTER: Bornstein B 

PROVIDER: S-EPMC9931388 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature