Plant-made pharmaceuticals: exploring studies for the production of recombinant protein in plants and assessing challenges ahead.

ABSTRACT: The production of pharmaceutical compounds in plants is attracting increasing attention, as plant-based systems can be less expensive, safer, and more scalable than mammalian, yeast, bacterial, and insect cell expression systems. Here, we review the history and current status of plant-made pharmaceuticals. Producing pharmaceuticals in plants requires pairing the appropriate plant species with suitable transformation technology. Pharmaceuticals have been produced in tobacco, cereals, legumes, fruits, and vegetables via nuclear transformation, chloroplast transformation, transient expression, and transformation of suspension cell cultures. Despite this wide range of species and methods used, most such efforts have involved the nuclear transformation of tobacco. Tobacco readily generates larg

SUBMITTER: Lee J 

PROVIDER: S-EPMC9931573 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature