Tumour, whole-blood, plasma and tissue concentrations of metformin in lung cancer patients.

ABSTRACT:

Aim

Metformin is used for the management of type 2 diabetes mellitus (T2DM) and is being tested clinically as an anticancer agent. Metformin concentrations safely achievable in human solid tissues including tumours are unknown. This study was designed to determine metformin concentration in tissue compartments as a function of dose to inform rational dosing in preclinical models and interpretation of clinical results."

Methods

Subjects with solid tumours to be treated by resection and either (A) willingness to take metformin for 7-10 days before surgery or (B) taking metformin for T2DM were eligible. Whole blood, plasma, tumour, tumour-adjacent uninvolved tissue and subcutaneous adipose tissue were obtained for liquid chromatography with tandem mass spectrometry to measure m

SUBMITTER: Phillips JD 

PROVIDER: S-EPMC9931625 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature