Restricted physical activity after volumetric muscle loss alters whole-body and local muscle metabolism.

ABSTRACT: Volumetric muscle loss (VML) is the traumatic loss of skeletal muscle, resulting in chronic functional deficits and pathological comorbidities, including altered whole-body metabolic rate and respiratory exchange ratio (RER), despite no change in physical activity in animal models. In other injury models, treatment with β₂ receptor agonists (e.g. formoterol) improves metabolic and skeletal muscle function. We aimed first to examine if restricting physical activity following injury affects metabolic and skeletal muscle function, and second, to enhance the metabolic and contractile function of the muscle remaining following VML injury through treatment with formoterol. Adult male C57Bl/6J mice (n = 32) underwent VML injury to the posterior hindlimb compartment and were randomly as

SUBMITTER: Raymond-Pope CJ 

PROVIDER: S-EPMC9931639 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature