Chronic demyelination of rabbit lesions is attributable to failed oligodendrocyte progenitor cell repopulation.

ABSTRACT: The failure of remyelination in the human CNS contributes to axonal injury and disease progression in multiple sclerosis (MS). In contrast to regions of chronic demyelination in the human brain, remyelination in murine models is preceded by abundant oligodendrocyte progenitor cell (OPC) repopulation, such that OPC density within regions of demyelination far exceeds that of normal white matter (NWM). As such, we hypothesized that efficient OPC repopulation was a prerequisite of successful remyelination, and that increased lesion volume may contribute to the failure of OPC repopulation in human brain. In this study, we characterized the pattern of OPC activation and proliferation following induction of lysolecithin-induced chronic demyelination in adult rabbits. The density of OPCs never exc

SUBMITTER: Cooper JJM 

PROVIDER: S-EPMC9931654 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature