Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression.

ABSTRACT: Substantial follicle remodelling during the regression phase of the hair growth cycle is coordinated by the contraction of the dermal sheath smooth muscle, but how dermal-sheath-generated forces are regulated is unclear. Here, we identify spatiotemporally controlled endothelin signalling-a potent vasoconstriction-regulating pathway-as the key activating mechanism of dermal sheath contraction. Pharmacological blocking or genetic ablation of both endothelin receptors, ET_A and ET_B, impedes dermal sheath contraction and halts follicle regression. Epithelial progenitors at the club hair-epithelial strand bottleneck produce the endothelin ligand ET-1, which is required for follicle regression. ET signalling in dermal sheath cells and downstream contraction is dynamically re

SUBMITTER: Martino P 

PROVIDER: S-EPMC9931655 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature