Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample.

ABSTRACT:

Background

Substance use disorders (SUDs) are associated with a variety of co-occurring psychiatric disorders and other SUDs, which partly reflects genetic pleiotropy. Polygenic risk scores (PRSs) and phenome-wide association studies are useful in evaluating pleiotropic effects. However, the comparatively low prevalence of SUDs in population samples and the lack of detailed information available in electronic health records limit these data sets' informativeness for such analyses.

Methods

We used the deeply phenotyped Yale-Penn sample (n = 10,610 with genetic data; 46.3% African ancestry, 53.7% European ancestry) to examine pleiotropy for 4 major substance-related traits: alcohol use disorder, opioid use disorder, smoking initiation, and lifetime cannabis use. The sample inc

SUBMITTER: Kember RL 

PROVIDER: S-EPMC9931661 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature