An optimized radiosynthesis of [¹⁸ F]DK222, a PET radiotracer for imaging PD-L1.

ABSTRACT: A radiochemical synthesis of [¹⁸ F]DK222, a peptide binder of programmed death ligand 1 protein, suitable for human PET studies is described, and results from validation productions are presented. The high specific activity radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice (cGMP) requirements. In addition, the production is extended to use a commercial synthesizer platform (General Electric FASTlab 2).

SUBMITTER: Holt DP 

PROVIDER: S-EPMC9931671 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature