Angiotensin II Type 1A Receptor Expressed in Smooth Muscle Cells is Required for Hypertensive Vascular Remodeling in Mice Infused With Angiotensin II.

ABSTRACT:

Background

Ang II (angiotensin II) type 1 (AT₁) receptors play a critical role in cardiovascular diseases such as hypertension. Rodents have 2 types of AT₁ receptor (AT_1A and AT_1B) of which knock-in Tagln-mediated smooth muscle AT_1A silencing attenuated Ang II-induced hypertension. Although vascular remodeling, a significant contributor to organ damage, occurs concurrently with hypertension in Ang II-infused mice, the contribution of smooth muscle AT_1A in this process remains unexplored. Accordingly, it is hypothesized that smooth muscle AT_1A receptors exclusively contribute to both medial thickening and adventitial fibrosis regardless of the presence of hypertension.

Methods

About 1 µg/kg pe

SUBMITTER: Okuno K 

PROVIDER: S-EPMC9931681 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature