Application of a physiologically based pharmacokinetic model in predicting captopril disposition in children with chronic kidney disease.

ABSTRACT: Over the last several decades, angiotensin-converting enzyme inhibitors (ACEIs) have been a staple in the treatment of hypertension and renovascular disorders in children. One of the ACEIs, captopril, is projected to have all the benefits of traditional vasodilators. However, conducting clinical trials for determining the pharmacokinetics (PK) of a drug is challenging, particularly in pediatrics. As a result, modeling and simulation methods have been developed to identify the safe and effective dosages of drugs. The physiologically based pharmacokinetic (PBPK) modeling is a well-established method that permits extrapolation from adult to juvenile populations. By using SIMCYP simulator, as a modeling platform, a previously developed PBPK drug-disease model of captopril was scaled to renally

SUBMITTER: Khalid S 

PROVIDER: S-EPMC9931704 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature