Lymphangioleiomyomatosis: Searching for potential biomarkers.

ABSTRACT:

Background

Vascular endothelial growth factor-D (VEGF-D) is the most commonly used biomarker for diagnosing lymphangioleiomyomatosis (LAM). However, lung biopsy is often necessary as well; therefore, defining new biomarkers for LAM is crucial. The aim of this study was to describe the diagnostic accuracy of a variety of biomarkers.

Methods

We assessed 13 analytes in serum related to extracellular matrix remodeling, lymphatic involvement and angiogenesis in a cohort of patients with LAM, comparing them with patients with other cystic lung diseases (OCLD) and healthy women. A scoring method based on the cut-point of each VEGF-D and metalloproteinase-2 (MMP-2) was used to evaluate the diagnostic performance of the marker combination.

Results

A total of 97 subjects were r

SUBMITTER: Revilla-Lopez E 

PROVIDER: S-EPMC9931739 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature