Ontology highlight
ABSTRACT:
SUBMITTER: van Amerongen RA
PROVIDER: S-EPMC9931760 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
van Amerongen Rosa A RA Morton Laura T LT Chaudhari Umesh G UG Remst Dennis F G DFG Hagedoorn Renate S RS van den Berg Cathelijne W CW Freund Christian C Falkenburg J H Frederik JHF Heemskerk Mirjam H M MHM
Molecular therapy. Methods & clinical development 20230120
The balance between safety and efficacy of T cell therapies remains challenging and T cell mediated toxicities have occurred. The stringent selection of tumor-specific targets and careful selection of tumor-specific T cells using T cell toxicity screenings are essential. <i>In vitro</i> screening options against vital organs or specialized cell subsets would be preferably included in preclinical pipelines, but options remain limited. Here, we set up preclinical models with human induced pluripot ...[more]