Breast cancer: emerging principles of metastasis, adjuvant and neoadjuvant treatment from cancer registry data.

ABSTRACT:

Purpose

Growing primary breast cancers (PT) can initiate local recurrences (LR), regional lymph nodes (pLN) and distant metastases (MET). Components of these progressions are initiation, frequency, growth duration, and survival. These characteristics describe principles which proposed molecular concepts and hypotheses must align with.

Methods

In a population-based retrospective modeling approach using data from the Munich Cancer Registry key steps and factors associated with metastasis were identified and quantified. Analysis of 66.800 patient datasets over four time periods since 1978, reliable evidence is obtained even in small subgroups. Together with results of clinical trials on prevention and adjuvant treatment (AT) principles for the MET process and AT are derived.

SUBMITTER: Engel J 

PROVIDER: S-EPMC9931789 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature