[¹⁸F]FAPI-42 PET/CT in differentiated thyroid cancer: diagnostic performance, uptake values, and comparison with 2-[¹⁸F]FDG PET/CT.

ABSTRACT:

Purpose

This study aimed to assess the diagnostic performance of [¹⁸F]FAPI-42 PET/CT and compare it with that of 2-[¹⁸F]FDG PET/CT in patients with differentiated thyroid cancer (DTC) with biochemical elevations in Tg or anti-Tg antibodies.

Methods

A total of 42 patients with DTC with biochemical elevations in Tg or anti-Tg antibodies underwent [¹⁸F]FAPI-42 PET/CT as part of this study; of which, 11 additionally underwent 2-[¹⁸F]FDG PET/CT within 7 days. Images were semi-quantitatively and visually interpreted, and the quantity, location, and uptake values of lesions were noted. The diagnostic capacity of [¹⁸F]FAPI-42 PET/CT and biomarkers affecting the uptake of [¹⁸F]FAPI-42 were evaluated. In addition, the d

SUBMITTER: Mu X 

PROVIDER: S-EPMC9931817 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature