Genetically predicted obesity and risk of hip osteoarthritis.

ABSTRACT:

Objectives

To determine the causal association between genetically predicted obesity and the risk of hip osteoarthritis.

Methods

We performed two-sample Mendelian randomization (MR) analysis to analyze the association between body mass index (BMI) and hip osteoarthritis using pooled-level genome-wide association study (GWAS) data. The inverse variance weighted (IVW), MR‒Egger, and weighted median methods were used to estimate the causal association. In addition, we applied the MR Steiger filtering method, MR robust adjusted profile score (MR.RAPS) methods, and the MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) global test to examine and address potential horizontal pleiotropy.

Results

We found a causal relationship between genetically predicted BMI and the risk of

SUBMITTER: Yuan J 

PROVIDER: S-EPMC9931853 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature