Glioblastoma PET/MRI: kinetic investigation of [¹⁸F]rhPSMA-7.3, [¹⁸F]FET and [¹⁸F]fluciclovine in an orthotopic mouse model of cancer.

ABSTRACT:

Purpose

Glioblastoma multiforme (GBM) is the most common glioma and standard therapies can only slightly prolong the survival. Neo-vascularization is a potential target to image tumor microenvironment, as it defines its brain invasion. We investigate [¹⁸F]rhPSMA-7.3 with PET/MRI for quantitative imaging of neo-vascularization in GBM bearing mice and human tumor tissue and compare it to [¹⁸F]FET and [¹⁸F]fluciclovine using PET pharmacokinetic modeling (PKM).

Methods

[¹⁸F]rhPSMA-7.3, [¹⁸F]FET, and [¹⁸F]fluciclovine were i.v. injected with 10.5 ± 3.1 MBq, 8.0 ± 2.2 MBq, 11.5 ± 1.9 MBq (n = 28, GL261-luc2) and up to 90 min PET/MR imaged 21/28 days after surgery. Regions of interest were delineated on T2-weighted M

SUBMITTER: Lindemann M 

PROVIDER: S-EPMC9931868 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature