Role of mTOR inhibitor in the cellular and humoral immune response to a booster dose of SARS-CoV-2 mRNA-1273 vaccine in kidney transplant recipients.

ABSTRACT:

Background

Immunocompromised patients have an increased risk of developing severe COVID disease, as well as a tendency to suboptimal responses to vaccines. The objective of this study was to evaluate the specific cellular and humoral adaptive immune responses of a cohort of kidney transplant recipients (KTR) after 3 doses of mRNA-1273 vaccine and to determinate the main factors involved.

Methods

Prospective observational study in 221 KTR (149 non infected), 55 healthy volunteers (HV) and 23 dialysis patients (DP). We evaluated anti-spike (by quantitative chemiluminescence immunoassay) and anti-nucleocapsid IgG (ELISA), percentage of TCD4⁺ and TCD8⁺ lymphocytes producing IFNγ against S-protein by intracellular flow cytometry after Spike-specific 15-mer p

SUBMITTER: Perez-Flores I 

PROVIDER: S-EPMC9931894 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature