Is single fraction the future of stereotactic body radiation therapy (SBRT)? A critical appraisal of the current literature.

ABSTRACT: Stereotactic Body Radiation Therapy (SBRT) is a standard of care for many localizations but the question of the optimal fractionation remains a matter of concern. If single fraction sessions are routinely used for intracranial targets, their utilization for mobile extracranial lesions is a source of debate and apprehension. Single session treatments improve patient comfort, provide a medico-economic benefit, and have proven useful in the context of the SARS-CoV 2 pandemic. However, both technical and radiobiological uncertainties remain. Experience from intracranial radiosurgery has shown that the size of the target, its proximity to organs at risk, tumor histology, and the volume of normal tissue irradiated are all determining factors in the choice of fractionation. The literature on the

SUBMITTER: Terlizzi M 

PROVIDER: S-EPMC9931895 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature