IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination.

ABSTRACT: Previously we reported that a recombinant HSV-1 expressing murine IL-2 (HSV-IL-2) causes CNS demyelination in different strains of mice and in a T cell-dependent manner. Since T_H17 cells have been implicated in CNS pathology, in the present study, we looked into the effects of IL-17A^-/- and three of its receptors on HSV-IL-2-induced CNS demyelination. IL-17A^-/- mice did not develop CNS demyelination, while IL-17RA^-/-, IL-17RC^-/-, IL-17RD^-/- and IL-17RA^-/-RC^-/- mice developed CNS demyelination. Adoptive transfer of T cells from wild-type (WT) mice to IL-17A^-/- mice or T cells from IL-17A^-/- mice to Rag^-/- mice induced CNS demyelination in infected mice. Adoptive T cell ex

SUBMITTER: Hirose S 

PROVIDER: S-EPMC9931899 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature