A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases.

ABSTRACT: A major evolution from purely clinical diagnoses to biomarker supported clinical diagnosing has been occurring over the past years in neurology. High-throughput methods, such as next-generation sequencing and mass spectrometry-based proteomics along with improved neuroimaging methods, are accelerating this development. This calls for a consensus framework that is broadly applicable and provides a spot-on overview of the clinical validity of novel biomarkers. We propose a harmonized terminology and a uniform concept that stratifies biomarkers according to clinical context of use and evidence levels, adapted from existing frameworks in oncology with a strong focus on (epi)genetic markers and treatment context. We demonstrate that this framework allows for a consistent assessment of clinical

SUBMITTER: Bernhardt AM 

PROVIDER: S-EPMC9931915 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature