Development and evaluation of the Acromegaly Symptom Diary.

ABSTRACT:

Background

Patient-reported outcome (PRO) measures are important to consider when evaluating treatments, yet there are no PRO measures for patients with acromegaly that have been developed in accordance with US Food and Drug Administration guidance. Acromegaly is a rare, chronic condition caused by hypersecretion of growth hormone. Disease activity is monitored by measurement in serum of growth hormone and insulin-like growth factor-I. The objectives of this research were to develop the Acromegaly Symptom Diary (ASD), establish a scoring algorithm, and evaluate the psychometric measurement properties of the ASD.

Methods

Semistructured interviews consisting of concept elicitation and cognitive debriefing components were conducted with 16 adult participants with acromegaly. Th

SUBMITTER: Martin S 

PROVIDER: S-EPMC9931976 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature