Instrumental variable-based high-dimensional mediation analysis with unmeasured confounders for survival data in the observational epigenetic study.

ABSTRACT: Background: High dimensional mediation analysis is frequently conducted to explore the role of epigenetic modifiers between exposure and health outcome. However, the issue of high dimensional mediation analysis with unmeasured confounders for survival analysis in observational study has not been well solved. Methods: In this study, we proposed an instrumental variable based approach for high dimensional mediation analysis with unmeasured confounders in survival analysis for epigenetic study. We used the Sobel's test, the Joint test, and the Bootstrap method to test the mediation effect. A comprehensive simulation study was conducted to decide the best test strategy. An empirical study based on DNA methylation data of lung cancer patients was conducted to illustrate the perfor

SUBMITTER: Chen F 

PROVIDER: S-EPMC9932046 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature