Ontology highlight
ABSTRACT:
SUBMITTER: Griffett K
PROVIDER: S-EPMC9932051 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Griffett Kristine K Burris Thomas P TP
Frontiers in medicine 20230202
Activation of LXR activity by synthetic agonists has been the focus of many drug discovery efforts with a focus on treatment of dyslipidemia and atherosclerosis. Many agonists have been developed, but all have been hindered due to their ability to efficaciously stimulate <i>de novo</i> lipogenesis. Here, we review the development of LXR inverse agonists that were originally optimized for their ability to enable recruitment of corepressors leading to silencing of genes that drive <i>de novo</i> l ...[more]