Construction of cuproptosis‐associated prognostic signature in colon adenocarcinoma based on bioinformatics and RT‐qPCR analysis

ABSTRACT: Colon adenocarcinoma (COAD) is the most common pathological subtype of colon cancer with a high degree of malignancy. Cuproptosis is a newly discovered copper-dependent cell death pattern distinguished from all the other known programmed cell death. Hence, it can be used as a potential therapeutic target for cancer. The present study aimed to clarify the relationship between cuproptosis and prognosis of COAD. The variations of 12 cuproptosis-associated genes based on 623 patients with COAD were comprehensively identified. It was found that 8 out of 12 were differentially expressed in tumors and normal tissues and CDKN2A showed a higher prognostic value. Therefore, two molecular subtypes were explored and the subtype A, with higher expression of cuproptosis-associated genes, showed more enr

SUBMITTER: Yang G 

PROVIDER: S-EPMC9932052 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature