TRPC7 facilitates cell growth and migration by regulating intracellular Ca²⁺ mobilization in lung adenocarcinoma cells.

ABSTRACT: Transient receptor potential canonical 7 (TRPC7) has been reported to mediate aging-associated tumorigenesis, but the role of TRPC7 in cancer malignancy is still unclear. TRPC7 is associated with tumor size in patients with lung adenocarcinoma and the present study further evaluated the underlying mechanism of TRPC7 in the regulation of cancer progression. The clinicopathological role of TRPC7 was assessed using immunohistochemistry staining and the pathological mechanism of TRPC7 in lung adenocarcinoma cells was determined using cell cycle examination, invasion and calcium response assays, and immunoblot analysis. The results indicated that high TRPC7 expression was associated with a lower 5-year survival rate compared with low TRPC7 expression, which suggested that TRPC7 expression was i

SUBMITTER: Liang JL 

PROVIDER: S-EPMC9932057 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature