Ontology highlight
ABSTRACT:
SUBMITTER: van Gen Hassend PM
PROVIDER: S-EPMC9932110 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
van Gen Hassend Pia Maria PM Pottikkadavath Aparna A Delto Carolyn C Kuhn Monika M Endres Michelle M Schönemann Lars L Schindelin Hermann H
The Journal of biological chemistry 20230105 2
The CTLH (C-terminal to lissencephaly-1 homology motif) complex is a multisubunit RING E3 ligase with poorly defined substrate specificity and flexible subunit composition. Two key subunits, muskelin and Wdr26, specify two alternative CTLH complexes that differ in quaternary structure, thereby allowing the E3 ligase to presumably target different substrates. With the aid of different biophysical and biochemical techniques, we characterized CTLH complex assembly pathways, focusing not only on Wdr ...[more]