Ontology highlight
ABSTRACT:
SUBMITTER: Grosgeorges M
PROVIDER: S-EPMC9932139 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Grosgeorges Marie M Picque Lasorsa Laurence L Pastor Brice B Prévostel Corinne C Crapez Evelyne E Sanchez Cynthia C Frayssinoux Florence F Jarlier Marta M Pezzella Véronique V Monard Laure L Ychou Marc M Thierry Alain R AR Mazard Thibault T Blache Philippe P
Scientific reports 20230215 1
Optimizing the biomarker combination to be analyzed in liquid biopsies should improve personalized medicine. We developed a method to purify circulating cell-free mRNAs from plasma samples and to quantify them by RT-qPCR. We selected three candidate colorectal cancer biomarkers (B2M, TIMP-1, and CLU). Their mRNA levels were significantly higher in plasma of patients with metastatic colorectal cancer patients (mCRC) (n = 107) than in healthy individuals (HI) (n = 53). To increase the discriminati ...[more]