Regulation of beige adipocyte thermogenesis by the cold-repressed ER protein NNAT.

ABSTRACT:

Objective

Cold stimuli trigger the conversion of white adipose tissue into beige adipose tissue, which is capable of non-shivering thermogenesis. However, what process drives this activation of thermogenesis in beige fat is not well understood. Here, we examine the ER protein NNAT as a regulator of thermogenesis in adipose tissue.

Methods

We investigated the regulation of adipose tissue NNAT expression in response to changes in ambient temperature. We also evaluated the functional role of NNAT in thermogenic regulation using Nnat null mice and primary adipocytes that lack or overexpress NNAT.

Results

Cold exposure or treatment with a β3-adrenergic agonist reduces the expression of adipose tissue NNAT in mice. Genetic disruption of Nnat in mice enhances inguinal adipos

SUBMITTER: Choi KM 

PROVIDER: S-EPMC9932177 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature