MnO₂@Au nanostructures supported colorimetric biosensing with duplex-specific nuclease-assisted DNA structural transition.

ABSTRACT: Manganese dioxide (MnO₂) nanosheets are regarded as a new class of two-dimensional nanomaterials with several attractive properties with enormous progress in biomedical fields. Gold nanoparticles (AuNPs) are also important biocompatible nanomaterials with unusual optical properties. Hetero-nanostructure of MnO₂ and AuNPs with the medium of DNA is an interesting topic. In this work, the protection of the hetero-nanostructure from salt-induced aggregation is systematically investigated including the effects of sequence length, reagents concentrations, incubation time and temperature. The MnO₂@Au nanostructures are thus applied for the analysis of miRNA. Duplex-specific nuclease (DSN) catalyzed digestion, hybridization chain reaction (HCR) and catalytic hairpi

SUBMITTER: Ma X 

PROVIDER: S-EPMC9932214 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature