Discrimination and learning of temporal input sequences in a cerebellar Purkinje cell model.

ABSTRACT:

Introduction

Temporal information processing is essential for sequential contraction of various muscles with the appropriate timing and amplitude for fast and smooth motor control. These functions depend on dynamics of neural circuits, which consist of simple neurons that accumulate incoming spikes and emit other spikes. However, recent studies indicate that individual neurons can perform complex information processing through the nonlinear dynamics of dendrites with complex shapes and ion channels. Although we have extensive evidence that cerebellar circuits play a vital role in motor control, studies investigating the computational ability of single Purkinje cells are few.

Methods

We found, through computer simulations, that a Purkinje cell can discriminate a series of pul

SUBMITTER: Tamura K 

PROVIDER: S-EPMC9932327 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature