Prognostic biomarker NEIL3 and its association with immune infiltration in renal clear cell carcinoma.

ABSTRACT:

Background

Kidney renal clear cell carcinoma (KIRC) is a malignant tumor with a high degree of immune infiltration. Identifying immune biomarkers is essential for the treatment of KIRC. Studies have identified the potential of NEIL3 to modulate the immune microenvironment and promote tumor progression. However, the role of NEIL3 in KIRC remains uncertain. This study was to investigate the effect of NEIL3 on the prognosis and immune infiltration of patients with KIRC.

Methods

TCGA and GEO databases were used to study the expression of NEIL3 in KIRC. Cox regression analysis was used to examine the relationship between the expression of NEIL3 and clinicopathological variables and survival. Furthermore, Gene Set Cancer Analysis (GSCA) was applied to study the impact of NEIL3 met

SUBMITTER: Sun X 

PROVIDER: S-EPMC9932331 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature