Cerebral blood flow quantification with multi-delay arterial spin labeling in ischemic stroke and the association with early neurological outcome

ABSTRACT: Highlights • Multi-PLD ASL allows quantification of cerebral blood flow in ischemic stroke.• Hyperperfusion in ischemic regions is common after recanalization with EVT.• Early neurological outcome is positively associated with the level of reperfusion. Restoring blood flow to brain tissue at risk of infarction is essential for tissue survival and clinical outcome. We used cerebral blood flow (CBF) quantified with multiple post-labeling delay (PLD) pseudocontinuous arterial spin labeling (ASL) MRI after ischemic stroke and assessed the association between CBF and early neurological outcome. We acquired ASL with 7 PLDs at 3.0 T in large vessel occlusion stroke patients at 24 h. We quantified CBF relative to the contralateral hemisphere (rCBF) and defined hyperperfusion as a ≥30% increase and

SUBMITTER: Luijten S 

PROVIDER: S-EPMC9932490 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature