Short-term effects of Chlorhexidine mouthwash and Listerine on oral microbiome in hospitalized patients.

ABSTRACT:

Introduction

Chlorhexidine (CHX) and essential oil containing mouthwashes like Listerine^® can improve oral hygiene via suppressing oral microbes. In hospitalized patients, CHX mouthwash reduces the incidence of ventilator-associated pneumonia. However, CHX use was also associated with increased mortality, which might be related to nitrate-reducing bacteria. Currently, no study determines oral bacteria targeted by essential oils mouthwash in hospitalized patients using a metagenomic approach.

Methods

We recruited 87 hospitalized patients from a previous randomized control study, and assigned them to three mouthwash groups: CHX, Listerine, and normal saline (control). Before and after gargling the mouthwash twice a day for 5-7 days, oral bacteria were examine

SUBMITTER: Liu T 

PROVIDER: S-EPMC9932516 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature