Multiscale photoacoustic tomography using reversibly switchable thermochromics

ABSTRACT: Abstract.

Significance

Based on acoustic detection of optical absorption, photoacoustic tomography (PAT) allows functional and molecular imaging beyond the optical diffusion limit with high spatial resolution. However, multispectral functional and molecular PAT is often limited by decreased spectroscopic accuracy and reduced detection sensitivity in deep tissues, mainly due to wavelength-dependent optical attenuation and inaccurate acoustic inversion.

Aim

Previous work has demonstrated that reversible color-shifting can drastically improve the detection sensitivity of PAT by suppressing nonswitching background signals. We aim to develop a new color switching-based PAT method using reversibly switchable thermochromics (ReST).

Approach

We developed a family of ReST

SUBMITTER: Ma C 

PROVIDER: S-EPMC9932525 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature