Highly expressed CENPL is correlated with breast cancer cell proliferation and immune infiltration.

ABSTRACT:

Background

Centromere protein L (CENPL) is associated with a variety of human diseases. However, its function in breast cancer remains uncertain.

Methods

The Cancer Genome Atlas (TCGA) and genotype-tissue expression across cancer data were used to investigate CENPL expression. Using TCGA clinical survival data, the relationship between CENPL expression and patient prognosis was assessed. Using the cluster profiler R software tool, enrichment analysis of CENPL was carried out. Additionally, by studying the TCGA database, the relationship between CENPL expression and immune cell infiltration was assessed. To evaluate CENPL's impact on breast cancer cell proliferation, the CCK8 test and colony-formation assay were carried out. Scratch testing and the transwell assay were used t

SUBMITTER: Gui Z 

PROVIDER: S-EPMC9932532 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature