Mortalin: Protein partners, biological impacts, pathological roles, and therapeutic opportunities.

ABSTRACT: Mortalin (GRP75, HSPA9A), a heat shock protein (HSP), regulates a wide range of cellular processes, including cell survival, growth, and metabolism. The regulatory functions of mortalin are mediated through a diverse set of protein partners associated with different cellular compartments, which allows mortalin to perform critical functions under physiological conditions, including mitochondrial protein quality control. However, alteration of mortalin's activities, its abnormal subcellular compartmentalization, and its protein partners turn mortalin into a disease-driving protein in different pathological conditions, including cancers. Here, mortalin's contributions to tumorigenic pathways are explained. Pathology information based on mortalin's RNA expression extracted from The Cancer Geno

SUBMITTER: Esfahanian N 

PROVIDER: S-EPMC9932541 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature