Genetic Associations Between Smoking- and Glaucoma-Related Traits.

ABSTRACT:

Purpose

The purpose of this study was to describe the genetic relationship between smoking and glaucoma.

Methods

We used summary-level genetic data for smoking initiation, smoking intensity (cigarettes per day [CPD]), intraocular pressure (IOP), vertical cup-disc ratio, and open-angle glaucoma (OAG) to estimate global genetic correlations (rg) and perform two-sample Mendelian randomization (MR) experiments that explored relations between traits. Finally, we examined associations between smoking genetic risk scores (GRS) and smoking traits with measured IOP and OAG in Rotterdam Study participants.

Results

We identified weak inverse rg between smoking- and glaucoma-related traits that were insignificant after Bonferroni correction. However, MR analysis revealed that gen

SUBMITTER: Tran JH 

PROVIDER: S-EPMC9932549 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature